Urokinase pulmonary embolism trial
Read Online

Urokinase pulmonary embolism trial a national cooperative study.

  • 24 Want to read
  • ·
  • 83 Currently reading

Published by American Heart Association in New York .
Written in English


  • Pulmonary embolism.,
  • Urokinase.

Book details:

Edition Notes

StatementEditorial committee: Arthur A. Sasahara, chairman [and others]
SeriesAmerican Heart Association. Monograph, no. 39, Supplement 2 to Circulation, v. 47-48, April,, 1973, Circulation., 1973, no. 2., American Heart Association monograph ;, no. 39.
ContributionsSasahara, Arthur A. 1927- ed.
LC ClassificationsRC776.P85 U76
The Physical Object
Pagination108 p.
Number of Pages108
ID Numbers
Open LibraryOL5429052M
LC Control Number73075149

Download Urokinase pulmonary embolism trial


  In a randomized, national cooperative trial, urokinase and subsequent heparin sodium therapy, when compared to heparin therapy alone, significantly accelerated the resolution rate of pulmonary thromboemboli at 24 hours as shown by pulmonary arteriograms, lung scans, and right-sided pressure measurements. No significant differences in recurrence rate of pulmonary embolism .   To the Editor.— A hour infusion of urokinase was shown to accelerate the resolution rate of pulmonary thromboemboli more than did a similar infusion of heparin (, ). However, " urokinase regimen did not usually achieve complete thrombolysis." The lack of dramatic thrombolysis may well be ascribed to the short duration of the urokinase by:   A preliminary report regarding the results of the Urokinase-Pulmonary Embolism Trial appeared in JAMA 1 in The entire concept, specific aims, and results of this trial were published in Circulation 2 in Still, there remains a misconception regarding the purpose of this trial and there have been gross misinterpretations of the results. 3 This study was not a therapeutic trial, and Cited by: 3. the Urokinase Pulmonary Embolism Trial (2) and approved by the U.S. Food and Drug Administration in (that is, 4, U/kg as an intravenous bolus infusion, followed by .

The urokinase pulmonary embolism trial: A national cooperative study. Circulation. ; II–II [Google Scholar] Dalla-Volta S, Palla A, Santolicandro A, et al. PAIMS 2: Alteplase combined with heparin versus heparin in the treatment of acute pulmonary embolism. Plasminogen activator Italian multicenter study 2.   The dose of urokinase ('Abbokinase' Abbott) was that specified for phase I of the Urokinase Pulmonary Embolism Trial (UPET): U/lb body-weight as an intravenous bolus dose followed by U/Ib/h for 24 h.6 Our protocol required discontinuation of urokinase after 2 h of therapy if the 2 h angiogram was judged to show any clot lysis; if there was no evidence of clot lysis then . Background: Systemic thrombolysis for acute pulmonary embolism (PE) carries up to a 20% risk of major bleeding, including a 2% to 5% risk of hemorrhagic stroke. We evaluated the safety and effectiveness of catheter-directed therapy (CDT) as an alternative treatment of acute PE. Methods: One hundred one consecutive patients receiving CDT for acute PE were prospectively enrolled in a .   In , the Urokinase Pulmonary Embolism Trial (UPET) was conducted to define the efficacy of thrombolytic therapy in PE. 63 In this randomized prospective controlled trial, patients were randomized to standard IV heparin therapy with and without an infusion of urokinase. Using pulmonary angiograms, lung scans, and right-sided pressure measurements, no significant differences in the .

  Meyer G, Sors H, Charbonnier B, et al. Effects of intravenous urokinase versus alteplase on total pulmonary resistance in acute massive pulmonary embolism: a European multicenter double-blind trial. J Am Coll Cardiol. ; – Pulmonary embolism occurs when a detached thrombus (embolism) from any part of the venous territory becomes lodged in the pulmonary artery. Although the origin of the embolism may be venous thrombosis in any location (upper extremities, prostatic, uterine and renal veins and right heart chambers), it is a lower extremity deep vein thrombosis in. The Urokinase pulmonary embolism trial; a national cooperative study.. [Arthur A Sasahara;] Home. WorldCat Home About WorldCat Help. Search. Search for Library Items Search for Lists Search for Contacts Search for a Library. Create Book\/a>, schema:CreativeWork\/a> ;.   Pulmonary embolism (PE) remains poorly understood. Rates of clinical outcomes such as death and recurrence vary widely among trials. We therefore established the International Cooperative Pulmonary Embolism Registry (ICOPER), with .